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KMID : 1132720130110030149
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Genomics & Informatics
2013 Volume.11 No. 3 p.149 ~ p.154
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Genome-Wide Association Study of Liver Enzymes in Korean Children
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Park Tae-Joon
Hwang Joo-Yeon
Go Min-Jin
Lee Hye-Ja
Jang Han-Byul
Choi Young-Shim
Kang Jae-Heon
Park Kyung-Hee
Choi Min-Gyu
Song Ji-Hyun
Kim Bong-Jo
Lee Jong-Young
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Abstract
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Liver enzyme elevations, as an indicator of liver function, are widely associated with metabolic diseases. Genome-wide population-based association studies have identified a genetic susceptibility to liver enzyme elevations and their related traits; however, the genetic architecture in childhood remains largely unknown. We performed a genome-wide association study to identify new genetic loci for liver enzyme levels in a Korean childhood cohort (n = 484). We observed three novel loci (rs4949718, rs80311637, and rs596406) that were multiply associated with elevated levels of alanine transaminase and aspartate transaminase. Although there are some limitations, including genetic power, additional replication and functional characterization will support the clarity on the genetic contribution that the ST6GALNAC3, ADAMTS9, and CELF2 genes have in childhood liver function.
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KEYWORD
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alanine transaminase, aspartate transaminase, childhood liver enzyme, genome-wide association study
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